Four Artifacts of the Universe?

Ok, I have a question I am working on a story and in the story I am trying to come up with four artifacts, artifacts that sort of kind of are involved with the universe. I was wondering if people can give examples of artifacts, if you are confused an example of an artifact would be from the series W.I.T.C.H, the heart of Earth is Lillian Hale, so if anyone has any example please answer my question.